Anna Harrison was too ill to travel when her husband set out from Ohio in 1841 for his inauguration. It was a long trip and a difficult one even by steamboat and railroad, with February weather uncertain at best, and she at age 65 was well acquainted with the rigors of frontier journeys.

Anna Symmes was born on July 25, 1775 in Morristown, New Jersey. At 19, Anna traveled to Ohio with her father, Judge John Cleves Symmes, who had taken up land for settlement on the "north bend" of the Ohio River. She had grown up a young lady of the East, completing her education at a boarding school in New York City. A clandestine marriage on November 25, 1795, united Anna Symmes and Lt. William Henry Harrison, an experienced soldier at 22. Though the young man came from one of the best families of Virginia, Judge Symmes did not want his daughter to face the hard life of frontier forts; but eventually, seeing her happiness, he accepted her choice.

Though Harrison won fame as an Indian fighter and hero of the War of 1812, he spent much of his life in a civilian career. His service in Congress as territorial delegate from Ohio gave Anna and their two children a chance to visit his family at Berkeley, their plantation on the James River. Her third child was born on that trip, at Richmond in September 1800. Harrison’s appointment as governor of Indiana Territory took them even farther into the wilderness; he built a handsome house at Vincennes that blended fortress and plantation mansion. Anna gave birth to a total of ten children; their last child died in infancy.

When she decided not to go to Washington with him, the president-elect asked his daughter-in-law Jane Irwin Harrison, widow of his namesake son, to accompany him and act as hostess until Anna’s proposed arrival in May. Half a dozen other relatives happily went with them. On April 4, exactly one month after his inauguration, he died, so Anna never made the journey. She had already begun her packing when she learned of her loss.

Accepting grief with admirable dignity, she stayed at her home in North Bend until the house burned in 1858; she lived nearby with her last surviving child, John Scott Harrison, until she died on February 15, 1864 at the age of 88.