When William Henry Harrison's wife decided not to go to Washington with him, the president-elect asked his daughter-in-law Jane Irwin Harrison, widow of his namesake son, to accompany him and act as hostess until Anna's proposed arrival in May. Half a dozen other relatives happily went with them. On April 4, exactly one month after his inauguration, he died, so Anna never made the journey. She had already begun her packing when she learned of her loss.

Accepting grief with admirable dignity, she stayed at her home in North Bend until the house burned in 1858; she lived nearby with her last surviving child, John Scott Harrison, until she died in February 1864 at the age of 88.